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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Curcumenol, Cisplatin
Phytochemical Name Curcumenol (PubChem CID: 167812 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
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2D MOL 3D MOL
Structure of
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 268
Ref_1
Pair Name Curcumenol, Cisplatin
Disease Info [ICD-11: 2C77] Cervical cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Down-regulation Expression BCL2 hsa596
Up-regulation Expression CASP3 hsa836
Down-regulation Expression HIF1A hsa3091
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
Up-regulation Expression PARP1 hsa142
Down-regulation Expression YWHAG hsa7532
In Vitro Model HeLa Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_0030
C-33 A Human papillomavirus-independent cervical squamous cell carcinoma Homo sapiens (Human) CVCL_1094
Result Curcumenol can enhance cisplatin to inhibit cancer cell proliferation, migration, and invasion and promote tumor cell apoptosis. The combination of drugs may promote the apoptosis of cervical cancer cells through the YWHAG pathway.
03. Reference
No. Title Href
1 Curcumenol Targeting YWHAG Inhibits the Pentose Phosphate Pathway and Enhances Antitumor Effects of Cisplatin. Evid Based Complement Alternat Med. 2022 Jun 26;2022:3988916. doi: 10.1155/2022/3988916. Click
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